Grace expects Greinke trade to have emotional impa

first_img Grace expects Greinke trade to have emotional impact Former Cardinals kicker Phil Dawson retires After running back Andre Ellington’s career day — 15 carries for 154 yards and a touchdown — in the Arizona Cardinals’ 27-13 win over the Atlanta Falcons Sunday, the operative word that came to mind was ‘how.’ How did the talented rookie out of Clemson fall to the sixth round of 2013 NFL draft? How did the former All-ACC back get overlooked by every general manager not named Steve Keim? Top Stories Your browser does not support the audio element. 0 Comments   Share   The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Along with fellow rookie Stepfan Taylor, Ellington combined to give Arizona its first 200-yard rushing game since Beanie Wells paced the team to 268 yards on the ground back on Nov. 27, 2011. While Ellington, who started against Atlanta in place of Rashard Mendenhall (toe), has certainly proved himself to be a steal so far in 2013 with his team-leading 333 rushing yards, internally one of the major concerns has been whether or not the 5-foot-9 rookie is durable enough to handle a workload befitting of a starting running back.“I think if he continues to put up performances like [he did on Sunday], I think that will convince us all,” said Keim. “The bottom line is when you watch his run skills and his ability to avoid people and not take big hits on a consistent basis, I think that helps even though he’s a slightly-built guy.“But that ability to go from zero to 60 in seconds and to change the course of a game is obviously something we are excited about.” – / 18 The answer, at least in Keim’s estimation, has a lot to do with an untimely injury Ellington sustained before the NFL Combine.“He was fast on the college tape we all watched,” Keim told Arizona Sports 620’s Doug & Wolf Monday. “Again what is confusing at times is when guys don’t post particularly good times in Indy. Obviously, he tweaked his hamstring which is why he ran 4.61 coming out. And then he didn’t have a chance to run at his pro day, because his hamstring didn’t heal up in time. So he didn’t have a verified time better than 4.61 going into the draft.“You really had to go back and watch all of his college tape and try and add up all of his strengths. I say this often that we go out in the fall and fall in love with players, and then we spend four months in the spring confusing ourselves. That’s the perfect example of a guy who really did himself an injustice in the offseason, but we are just pleased to have him.”Pleased is probably a little bit of an understatement.Ellington’s first NFL start Sunday was highlighted by an 80-yard touchdown run in the second quarter — the third-longest in franchise history — and an impressive 10 yards per carry average. Derrick Hall satisfied with D-backs’ buying and selling LISTEN: Cardinals GM Steve Keim – Oct 28 last_img read more

-->

first_img Grace expects Greinke trade to have emotional impact Former Cardinals kicker Phil Dawson retires After running back Andre Ellington’s career day — 15 carries for 154 yards and a touchdown — in the Arizona Cardinals’ 27-13 win over the Atlanta Falcons Sunday, the operative word that came to mind was ‘how.’ How did the talented rookie out of Clemson fall to the sixth round of 2013 NFL draft? How did the former All-ACC back get overlooked by every general manager not named Steve Keim? Top Stories Your browser does not support the audio element. 0 Comments   Share   The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Along with fellow rookie Stepfan Taylor, Ellington combined to give Arizona its first 200-yard rushing game since Beanie Wells paced the team to 268 yards on the ground back on Nov. 27, 2011. While Ellington, who started against Atlanta in place of Rashard Mendenhall (toe), has certainly proved himself to be a steal so far in 2013 with his team-leading 333 rushing yards, internally one of the major concerns has been whether or not the 5-foot-9 rookie is durable enough to handle a workload befitting of a starting running back.“I think if he continues to put up performances like [he did on Sunday], I think that will convince us all,” said Keim. “The bottom line is when you watch his run skills and his ability to avoid people and not take big hits on a consistent basis, I think that helps even though he’s a slightly-built guy.“But that ability to go from zero to 60 in seconds and to change the course of a game is obviously something we are excited about.” – / 18 The answer, at least in Keim’s estimation, has a lot to do with an untimely injury Ellington sustained before the NFL Combine.“He was fast on the college tape we all watched,” Keim told Arizona Sports 620’s Doug & Wolf Monday. “Again what is confusing at times is when guys don’t post particularly good times in Indy. Obviously, he tweaked his hamstring which is why he ran 4.61 coming out. And then he didn’t have a chance to run at his pro day, because his hamstring didn’t heal up in time. So he didn’t have a verified time better than 4.61 going into the draft.“You really had to go back and watch all of his college tape and try and add up all of his strengths. I say this often that we go out in the fall and fall in love with players, and then we spend four months in the spring confusing ourselves. That’s the perfect example of a guy who really did himself an injustice in the offseason, but we are just pleased to have him.”Pleased is probably a little bit of an understatement.Ellington’s first NFL start Sunday was highlighted by an 80-yard touchdown run in the second quarter — the third-longest in franchise history — and an impressive 10 yards per carry average. Derrick Hall satisfied with D-backs’ buying and selling LISTEN: Cardinals GM Steve Keim – Oct 28 last_img read more

Croatian cable operator Bnet has added the Fox Mo

first_imgCroatian cable operator B.net has added the Fox Movies channel to its line-up to its Total TV service.The movie channel will air titles including X-Men, Lara Croft, Juno and The Queen.last_img

-->

first_imgCroatian cable operator B.net has added the Fox Movies channel to its line-up to its Total TV service.The movie channel will air titles including X-Men, Lara Croft, Juno and The Queen.last_img

Dear Enterprise Marketer Stop Growth Hacking

first_imgDear Enterprise Marketer, Stop Growth Hacking! Dmitri LisitskiApril 24, 2019, 4:25 pmApril 24, 2019 ABMAdobeInflu2Marketing Technology BlogPeople-based marketingSaasSales Previous ArticleMarin Software Research Reveals Shifting Patterns in Digital Ad SpendNext ArticleIgnitionOne uses Amazon Neptune to Power Identity Resolution at Scale Talk to Your Salespeople Instead.Let me share my biggest pain, the nightmare that is still keeping me up at night.Two years ago, when we launched Influ2, winning the first few customers was easy. Our product, person-based ads, was new and exciting. No one had ever done it before, so naturally many enterprise marketers were anxious to take it for a spin.But, these “wins” were delusions.What do you do as a digital marketer when you come across a new technology? You conduct an experiment. Spending a few thousand bucks on a new tool is no biggie for an enterprise marketer.So, you set up a low-budget ad campaign with a lead form at the landing page. You determine the success of the campaign by conversions — the number of people who fill in the form.Seems right, doesn’t it? Well, I can promise you with this metric you will get zero or almost zero conversions with person-based ads. In fact, you can run pretty much the same campaign targeting your CRM audience directly on social networks or online media — no need for a new trendy tool to do it.The idea to measure conversions by running experiments came from the e-commerce industry and found broad adoption among low-priced SaaS platforms like Slack, Twilio or Intercom.Now, every growth hacker will tell you to experiment with Google AdWords, Quora ads, LinkedIn promos, and the list goes on. Set up an experiment, run a campaign, track conversions, tune, repeat — that’s what thousands of marketers do, and since everyone does it, it must be right…Now, dear enterprise marketer, let’s think.Do you expect the CMO of Adobe to fill out a lead form to download your e-book? Is your e-book worth Ann Lewnes’s time and valuable contact details? Does she want your SDR to start bombarding her with drip sequences?I hear this over and over from our customers: No matter how good your targeting is, enterprise decision-makers don’t go for the lead forms. (Side note: If you got an enterprise CxO to fill out your lead form, let me know, and I’ll buy you dinner at the restaurant of your choice.)Recommended: Is Person-Based Marketing an Upgrade to ABM?This approach might work for selling sneakers to the mass market or $20 software subscriptions to SMBs, but it is very wrong for enterprise marketing. So, don’t listen to growth hackers. Your audience is fundamentally different.Who do you listen to then? Sorry, but it’s time to break your silo and talk to not-so-easy-going salespeople. Marketing spend pays off when it serves as an air cover for your sales team, especially for the sales development folks.Today, when launching proof-of-concept campaigns, we always ask new clients to talk to their sales department first. Ask them what accounts they are working on. These are your target audience. It’s so much easier for an SDR to talk to somebody who has recently seen your ads and who is aware of your product offering. When a prospect finds an email from your SDR and reacts with “I think I know these guys, it looks relevant, let’s talk” it’s simply because you’ve built an awareness with person-based ads.People don’t click on ads most of the time. So, when they do click, you know you got their attention; they are engaged. Imagine your outbound email goes to somebody who read an article about your company in Forbes yesterday. We are witnessing 3 – 5x better response rates from sales outreach that is in sync with person-based engagement signals compared to cold emails.Now, coming back to my nightmare. In marketing, you often defer to the “brand awareness” excuse when you can’t say if something worked or not but you know it should have. With person-based ads, we usually see around 30% improvement in SDRs’ productivity as a result of the air cover campaign. Our clients typically witness this within 3 months after the launch. However, we keep getting asked why there are no conversions from the lead forms over these 3 months… so my nightmare will recur.last_img read more

-->

first_imgDear Enterprise Marketer, Stop Growth Hacking! Dmitri LisitskiApril 24, 2019, 4:25 pmApril 24, 2019 ABMAdobeInflu2Marketing Technology BlogPeople-based marketingSaasSales Previous ArticleMarin Software Research Reveals Shifting Patterns in Digital Ad SpendNext ArticleIgnitionOne uses Amazon Neptune to Power Identity Resolution at Scale Talk to Your Salespeople Instead.Let me share my biggest pain, the nightmare that is still keeping me up at night.Two years ago, when we launched Influ2, winning the first few customers was easy. Our product, person-based ads, was new and exciting. No one had ever done it before, so naturally many enterprise marketers were anxious to take it for a spin.But, these “wins” were delusions.What do you do as a digital marketer when you come across a new technology? You conduct an experiment. Spending a few thousand bucks on a new tool is no biggie for an enterprise marketer.So, you set up a low-budget ad campaign with a lead form at the landing page. You determine the success of the campaign by conversions — the number of people who fill in the form.Seems right, doesn’t it? Well, I can promise you with this metric you will get zero or almost zero conversions with person-based ads. In fact, you can run pretty much the same campaign targeting your CRM audience directly on social networks or online media — no need for a new trendy tool to do it.The idea to measure conversions by running experiments came from the e-commerce industry and found broad adoption among low-priced SaaS platforms like Slack, Twilio or Intercom.Now, every growth hacker will tell you to experiment with Google AdWords, Quora ads, LinkedIn promos, and the list goes on. Set up an experiment, run a campaign, track conversions, tune, repeat — that’s what thousands of marketers do, and since everyone does it, it must be right…Now, dear enterprise marketer, let’s think.Do you expect the CMO of Adobe to fill out a lead form to download your e-book? Is your e-book worth Ann Lewnes’s time and valuable contact details? Does she want your SDR to start bombarding her with drip sequences?I hear this over and over from our customers: No matter how good your targeting is, enterprise decision-makers don’t go for the lead forms. (Side note: If you got an enterprise CxO to fill out your lead form, let me know, and I’ll buy you dinner at the restaurant of your choice.)Recommended: Is Person-Based Marketing an Upgrade to ABM?This approach might work for selling sneakers to the mass market or $20 software subscriptions to SMBs, but it is very wrong for enterprise marketing. So, don’t listen to growth hackers. Your audience is fundamentally different.Who do you listen to then? Sorry, but it’s time to break your silo and talk to not-so-easy-going salespeople. Marketing spend pays off when it serves as an air cover for your sales team, especially for the sales development folks.Today, when launching proof-of-concept campaigns, we always ask new clients to talk to their sales department first. Ask them what accounts they are working on. These are your target audience. It’s so much easier for an SDR to talk to somebody who has recently seen your ads and who is aware of your product offering. When a prospect finds an email from your SDR and reacts with “I think I know these guys, it looks relevant, let’s talk” it’s simply because you’ve built an awareness with person-based ads.People don’t click on ads most of the time. So, when they do click, you know you got their attention; they are engaged. Imagine your outbound email goes to somebody who read an article about your company in Forbes yesterday. We are witnessing 3 – 5x better response rates from sales outreach that is in sync with person-based engagement signals compared to cold emails.Now, coming back to my nightmare. In marketing, you often defer to the “brand awareness” excuse when you can’t say if something worked or not but you know it should have. With person-based ads, we usually see around 30% improvement in SDRs’ productivity as a result of the air cover campaign. Our clients typically witness this within 3 months after the launch. However, we keep getting asked why there are no conversions from the lead forms over these 3 months… so my nightmare will recur.last_img read more

Sprinklr Announces New Core Platform Functionality Live Slide Technology Enables the Rapid

first_imgLeading Brands Such as Michael Kors Are Using New Sprinklr Presentations Functionality to Present Real-Time Social Data With Ease and StyleSprinklr, the world’s first Unified Front Office Platform for Modern Channels, announced Sprinklr Presentations, a new function of the Core Platform, and available across all 5 Sprinklr products — Modern Marketing; Modern Advertising; Modern Research; Modern Care; and Modern Engagement. Sprinklr Presentations enables brands to present real-time social and business data in beautiful, engaging slide decks with unimaginable convenience.Today @Sprinklr announced Presentations helping brands turn real-time social and business data into beautiful decksThe Challenge: 20th century techniques for 21st century needs21st century modern channel data is dynamic and rapidly changing — crises can emerge in minutes and business results can change overnight. However, organizations create presentations of this information in a traditional cut and paste way, laboriously pulling social and business data from various dashboards and pasting them into slides. Employees hate it as they waste their weekends in assembly, and management is disappointed as the data is out of date by the time they see it. Literally, nobody is happy.Marketing Technology News: StarfishETL Partners with PeopleSense, Inc.The Solution: 21st century Live Slide TechnologySprinklr Presentations uses Live Slide technology to enable teams across the organization to collaborate build beautiful presentations with live, real-time social and business data using a simple drag and drop interface. Data is transformed into compelling presentations in minutes, customized to match the look and feel of any brand, updated automatically, and delivered to stakeholders in a PDF or a URL on any device.Marketing Technology News: Qlik Kicks Off AI In Action: The Qlik Analytics Tour, The Largest Roadshow In Data & Analytics“At Sprinklr, we are passionate about helping brands manage their entire front office – every customer-facing function including marketing, advertising, PR, and customer care,” says Pavitar Singh, CTO, Sprinklr. “We built Presentations to dramatically speed up the process of building slide decks and provide a better way to work with live data.”Marketing Technology News: Alorica Taps Business Transformation Veteran Colson Hillier to Be Chief Marketing Officer Sprinklr Announces New Core Platform Functionality: Live Slide Technology Enables the Rapid Creation of Beautiful Presentations which Feature Real-Time Data PRNewswireMay 27, 2019, 1:31 pmMay 27, 2019 Live Slide technologyMarketing Technologymodern marketingNewsSprinklrSprinklr PresentationsUnified Front Office Platform Previous ArticleSurveyMonkey Advances Cloud Operations in Europe for Enterprise Customers with Launch of Data CentreNext ArticleNICE Actimize’s AI-Infused Transaction Monitoring Solution to Transform China’s SPD Silicon Valley Bank AML Operationslast_img read more

-->

first_imgLeading Brands Such as Michael Kors Are Using New Sprinklr Presentations Functionality to Present Real-Time Social Data With Ease and StyleSprinklr, the world’s first Unified Front Office Platform for Modern Channels, announced Sprinklr Presentations, a new function of the Core Platform, and available across all 5 Sprinklr products — Modern Marketing; Modern Advertising; Modern Research; Modern Care; and Modern Engagement. Sprinklr Presentations enables brands to present real-time social and business data in beautiful, engaging slide decks with unimaginable convenience.Today @Sprinklr announced Presentations helping brands turn real-time social and business data into beautiful decksThe Challenge: 20th century techniques for 21st century needs21st century modern channel data is dynamic and rapidly changing — crises can emerge in minutes and business results can change overnight. However, organizations create presentations of this information in a traditional cut and paste way, laboriously pulling social and business data from various dashboards and pasting them into slides. Employees hate it as they waste their weekends in assembly, and management is disappointed as the data is out of date by the time they see it. Literally, nobody is happy.Marketing Technology News: StarfishETL Partners with PeopleSense, Inc.The Solution: 21st century Live Slide TechnologySprinklr Presentations uses Live Slide technology to enable teams across the organization to collaborate build beautiful presentations with live, real-time social and business data using a simple drag and drop interface. Data is transformed into compelling presentations in minutes, customized to match the look and feel of any brand, updated automatically, and delivered to stakeholders in a PDF or a URL on any device.Marketing Technology News: Qlik Kicks Off AI In Action: The Qlik Analytics Tour, The Largest Roadshow In Data & Analytics“At Sprinklr, we are passionate about helping brands manage their entire front office – every customer-facing function including marketing, advertising, PR, and customer care,” says Pavitar Singh, CTO, Sprinklr. “We built Presentations to dramatically speed up the process of building slide decks and provide a better way to work with live data.”Marketing Technology News: Alorica Taps Business Transformation Veteran Colson Hillier to Be Chief Marketing Officer Sprinklr Announces New Core Platform Functionality: Live Slide Technology Enables the Rapid Creation of Beautiful Presentations which Feature Real-Time Data PRNewswireMay 27, 2019, 1:31 pmMay 27, 2019 Live Slide technologyMarketing Technologymodern marketingNewsSprinklrSprinklr PresentationsUnified Front Office Platform Previous ArticleSurveyMonkey Advances Cloud Operations in Europe for Enterprise Customers with Launch of Data CentreNext ArticleNICE Actimize’s AI-Infused Transaction Monitoring Solution to Transform China’s SPD Silicon Valley Bank AML Operationslast_img read more

Singlecell encapsulation technology can protect transplanted MSCs from immune attack

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 16 2019Bone marrow transplants of hematopoietic stem cells have become standard treatment for a host of conditions including cancers of the blood and lymphatic systems, sickle cell anemia, inherited metabolic disorders, and radiation damage.Unfortunately, many bone marrow transplants fail due to rejection by the patient’s immune system or graft-versus-host disease (in which the transplanted marrow cells attack the patient’s healthy cells), both of which can be fatal. Mesenchymal stromal cells (MSCs) are known to secrete compounds that modulate the immune system and have shown promise in mitigating these problems in animal trials. However, clinical results with MSCs have been disappointing thus far, as they are rapidly cleared from the body and can draw attack from patients’ immune systems, and efforts to encapsulate MSCs in protective biomaterials have resulted in large, bulky hydrogels that cannot be given intravenously and compromise the cells’ functions.Today, in a scientific first, researchers from the Wyss Institute for Biologically Inspired Engineering, Harvard’s John A. Paulson School of Engineering and Applied Sciences (SEAS), and the Harvard Stem Cell Initiative (HSCI) demonstrate a single-cell encapsulation technology that effectively protects transplanted MSCs from clearance and immune attack and improves the success of bone marrow transplants in mice. The work is published in PNAS. Mao is also the lead of the Wyss Immuno-Materials Platform David Mooney, Ph.D. who is now a postdoc with Wyss Core Faculty member James Collins, Ph.DThis advance builds on a method the team previously developed that uses a microfluidic device to coat individual living cells with a thin layer of an alginate-based hydrogel, creating what they term “microgels.” The process encapsulates cells with 90% efficiency, and the resulting microgels are small enough that they can be delivered intravenously, unlike the bulky hydrogels created by other methods. When injected into mice, MSCs encapsulated using this technique remained in the animals’ lungs ten times longer than “bare” MSCs, and remained viable for up to three days.Because a large amount of MSCs’ clinical appeal lies in their secretion of compounds that modulate the body’s immune system, the researchers needed to test how microgel encapsulation affects MSCs’ ability to function and resist immune attack. They modified their original alginate microgel by adding another compound that cross-links to the alginate and makes the microgel stiffer and better able to resist the body’s immune system and clearance mechanisms. They also cultured the MSCs after encapsulation to encourage them to divide and produce more cells. When these new microgels were injected into mice, their persistence increased five-fold over the previous microgel design and an order of magnitude over bare MSCs.Related StoriesElectronic cigarettes produce stress response in neural stem cells, study findsBenefit of allogeneic stem cell transplantation in non-Hodgkin lymphoma remains unclearStudy provides new insight into how brain stem cells are activatedTo induce an immune response against the MSCs, the team incubated encapsulated cells in a medium containing fetal bovine serum, which is recognized by the body as foreign, before introducing them into mice. While the clearance rate of the encapsulated MSCs was higher than that observed without immune activation, it was still five times lower than that of bare MSCs. The microgels also outperformed bare MSCs when injected into mice that had a preexisting immune memory response against MSCs, which mimics human patients who are given multiple infusions of stem cells.MSCs exposed to inflammatory cytokines respond by increasing their expression of immune-modulating genes and proteins, so the researchers next tested whether encapsulation in their new microgels impacted this response. They found that bare and encapsulated MSCs had comparable levels of gene expression when exposed to the same cytokines, demonstrating that the microgels did not impair MSC performance.For their pièce de résistance, the team injected their MSC-containing microgels into mice along with transplanted bone marrow, half of which was immune-compatible with the recipient mouse and half of which was allogeneic, or an immune mismatch. Mice that received encapsulated MSCs had more than double the fraction of allogeneic bone marrow cells in their marrow and blood after nine days compared with mice that did not receive MSCs. Encapsulated MSCs also led to a greater degree of engraftment of the allogeneic cells into the host bone marrow compared to bare MSCs.”One of the strong points of this work is that it uses a completely non-genetic approach to dramatically increase cell survival in transplant contexts, where it’s sorely needed,” said Mooney, who is also the Robert P. Pinkas Family Professor of Bioengineering at SEAS. “This technology nicely complements genetic engineering approaches, and in fact could be more efficient than attempting to directly modify immune cells themselves.”The Wyss Institute’s Validation Project Program is supporting advancement of this approach as a possible treatment for ischemia (narrowing of blood vessels) in human patients, and hopes to demonstrate clinical viability in the near future. Validation Projects are technologies with potential high-impact applications that have successfully progressed through significant concept refinement and meet predefined technical, product development, and intellectual property criteria.”This technology simultaneously resolves multiple issues with bone marrow transplants and stem cell therapies using an elegant, biomaterials-based approach that represents the kind of cross-disciplinary thinking that we value so greatly at the Wyss Institute,” said Wyss Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at HMS and the Vascular Biology Program at Boston Children’s Hospital, as well as Professor of Bioengineering at SEAS. “We are excited to support this project as it moves toward clinical validation, and we look forward to other potential applications of microencapsulation to address drug and cell delivery problems.” Source:Wyss Institute for Biologically Inspired Engineering at Harvard To our knowledge, this is the first example of single-cell encapsulation being used to improve cell therapies, which are becoming more widespread as treatments for a number of diseases. And, our encapsulated cells can be frozen and thawed with minimal impact on the cells’ performance, which is critical in the context of hospitals and other treatment centers.”Angelo Mao, Ph.D., First Author and a Former Graduate Student in the lab of Wyss Core Faculty Memberlast_img read more

-->

first_imgReviewed by James Ives, M.Psych. (Editor)Jul 16 2019Bone marrow transplants of hematopoietic stem cells have become standard treatment for a host of conditions including cancers of the blood and lymphatic systems, sickle cell anemia, inherited metabolic disorders, and radiation damage.Unfortunately, many bone marrow transplants fail due to rejection by the patient’s immune system or graft-versus-host disease (in which the transplanted marrow cells attack the patient’s healthy cells), both of which can be fatal. Mesenchymal stromal cells (MSCs) are known to secrete compounds that modulate the immune system and have shown promise in mitigating these problems in animal trials. However, clinical results with MSCs have been disappointing thus far, as they are rapidly cleared from the body and can draw attack from patients’ immune systems, and efforts to encapsulate MSCs in protective biomaterials have resulted in large, bulky hydrogels that cannot be given intravenously and compromise the cells’ functions.Today, in a scientific first, researchers from the Wyss Institute for Biologically Inspired Engineering, Harvard’s John A. Paulson School of Engineering and Applied Sciences (SEAS), and the Harvard Stem Cell Initiative (HSCI) demonstrate a single-cell encapsulation technology that effectively protects transplanted MSCs from clearance and immune attack and improves the success of bone marrow transplants in mice. The work is published in PNAS. Mao is also the lead of the Wyss Immuno-Materials Platform David Mooney, Ph.D. who is now a postdoc with Wyss Core Faculty member James Collins, Ph.DThis advance builds on a method the team previously developed that uses a microfluidic device to coat individual living cells with a thin layer of an alginate-based hydrogel, creating what they term “microgels.” The process encapsulates cells with 90% efficiency, and the resulting microgels are small enough that they can be delivered intravenously, unlike the bulky hydrogels created by other methods. When injected into mice, MSCs encapsulated using this technique remained in the animals’ lungs ten times longer than “bare” MSCs, and remained viable for up to three days.Because a large amount of MSCs’ clinical appeal lies in their secretion of compounds that modulate the body’s immune system, the researchers needed to test how microgel encapsulation affects MSCs’ ability to function and resist immune attack. They modified their original alginate microgel by adding another compound that cross-links to the alginate and makes the microgel stiffer and better able to resist the body’s immune system and clearance mechanisms. They also cultured the MSCs after encapsulation to encourage them to divide and produce more cells. When these new microgels were injected into mice, their persistence increased five-fold over the previous microgel design and an order of magnitude over bare MSCs.Related StoriesElectronic cigarettes produce stress response in neural stem cells, study findsBenefit of allogeneic stem cell transplantation in non-Hodgkin lymphoma remains unclearStudy provides new insight into how brain stem cells are activatedTo induce an immune response against the MSCs, the team incubated encapsulated cells in a medium containing fetal bovine serum, which is recognized by the body as foreign, before introducing them into mice. While the clearance rate of the encapsulated MSCs was higher than that observed without immune activation, it was still five times lower than that of bare MSCs. The microgels also outperformed bare MSCs when injected into mice that had a preexisting immune memory response against MSCs, which mimics human patients who are given multiple infusions of stem cells.MSCs exposed to inflammatory cytokines respond by increasing their expression of immune-modulating genes and proteins, so the researchers next tested whether encapsulation in their new microgels impacted this response. They found that bare and encapsulated MSCs had comparable levels of gene expression when exposed to the same cytokines, demonstrating that the microgels did not impair MSC performance.For their pièce de résistance, the team injected their MSC-containing microgels into mice along with transplanted bone marrow, half of which was immune-compatible with the recipient mouse and half of which was allogeneic, or an immune mismatch. Mice that received encapsulated MSCs had more than double the fraction of allogeneic bone marrow cells in their marrow and blood after nine days compared with mice that did not receive MSCs. Encapsulated MSCs also led to a greater degree of engraftment of the allogeneic cells into the host bone marrow compared to bare MSCs.”One of the strong points of this work is that it uses a completely non-genetic approach to dramatically increase cell survival in transplant contexts, where it’s sorely needed,” said Mooney, who is also the Robert P. Pinkas Family Professor of Bioengineering at SEAS. “This technology nicely complements genetic engineering approaches, and in fact could be more efficient than attempting to directly modify immune cells themselves.”The Wyss Institute’s Validation Project Program is supporting advancement of this approach as a possible treatment for ischemia (narrowing of blood vessels) in human patients, and hopes to demonstrate clinical viability in the near future. Validation Projects are technologies with potential high-impact applications that have successfully progressed through significant concept refinement and meet predefined technical, product development, and intellectual property criteria.”This technology simultaneously resolves multiple issues with bone marrow transplants and stem cell therapies using an elegant, biomaterials-based approach that represents the kind of cross-disciplinary thinking that we value so greatly at the Wyss Institute,” said Wyss Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at HMS and the Vascular Biology Program at Boston Children’s Hospital, as well as Professor of Bioengineering at SEAS. “We are excited to support this project as it moves toward clinical validation, and we look forward to other potential applications of microencapsulation to address drug and cell delivery problems.” Source:Wyss Institute for Biologically Inspired Engineering at Harvard To our knowledge, this is the first example of single-cell encapsulation being used to improve cell therapies, which are becoming more widespread as treatments for a number of diseases. And, our encapsulated cells can be frozen and thawed with minimal impact on the cells’ performance, which is critical in the context of hospitals and other treatment centers.”Angelo Mao, Ph.D., First Author and a Former Graduate Student in the lab of Wyss Core Faculty Memberlast_img read more

Uber takes on commuting with Express car pool service

Citation: Uber takes on commuting with Express car pool service (2018, February 21) retrieved 18 July 2019 from https://phys.org/news/2018-02-uber-commuting-car-pool.html Uber on Wednesday maneuvered to become part of people’s daily commutes with the addition of an Express car pool to its ride-share options. Express Pool officially launched in a handful of US cities and was billed as an improvement on a car pool offering Uber has provided since 2014.Rather than have a driver travel to where each aspiring passenger requests a ride, the new Express option will use software to calculate the most direct path to the final destination and then have people walk to pick-up spots.”Riders wait a few minutes before their trips begin, and then walk a short distance to a nearby spot for pick up and drop off,” Uber shared rides product director Ethan Stock said in a release.”Walking and waiting help us make more optimal matches and provide better, straighter, faster routes with fewer detours, delivering an even more affordable and consistent option.”Car pooling leads to cheaper fares, and lets drivers take advantage of high-occupancy vehicle lanes on highways or discounted tolls where available.Nearly a billion riders have used Uber’s original car pool service, according to Stock.Using feedback from those riders, Uber “built the next generation of shared rides from the ground up,” Stock said.Why own cars?Uber software considers compatibility of passengers, proximity of drivers, and convenience of drop-off and pick-up locations, according to the San Francisco-based company.”The future of transportation in cities includes a shift towards more space-efficient modes of transportation and away from personal car ownership,” Zipcar co-founder Robin Chase said in the release.”Express Pool, in combination with public transit, cycling, car-sharing and more, can help us get towards this shift, and I’m extremely excited about the potential impact this product can have on cities.”A low-cost, convenient car pool service could also compete with public transit systems for commuter fares.Uber tested Express Pool in San Francisco and Boston, and is expanding it to six more US cities with the official launch this week.Uber, the titan in the ride share business, recently revealed that its losses last year swelled despite signs in the final three months that it was stemming the red ink.Figures reported by The Information and confirmed by AFP showed that Uber’s losses in 2017 grew to $4.5 billion from the $2.8 billion the San Francisco-based firm lost a year earlier.However, Uber lost $1.1 billion in the final quarter of 2017 as compared with $1.46 billion in the preceeding quarter as revenue rose.Net revenue grew to $2.22 billion from $1.38 billion in the same quarter-over-quarter comparison.Uber remains a private company, but routinely discloses some earnings information. Even as the company has seen unprecedented growth by expanding to dozens of countries, Uber has been hurt by allegations of executive misconduct, a toxic work atmosphere, and potentially unethical competitive practices.Dara Khosrowshahi, who was chosen as Uber CEO in August 2017, is steering the high-value startup to a stock market debut next year, and has vowed to fix the company’s work culture and business practices. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Uber’s express car pool option uses software to calculate the most direct path to the final destination and then has its customers meet at pick-up spots Uber loss leapt in 2017 as final quarter showed hope © 2018 AFP read more

-->

Citation: Uber takes on commuting with Express car pool service (2018, February 21) retrieved 18 July 2019 from https://phys.org/news/2018-02-uber-commuting-car-pool.html Uber on Wednesday maneuvered to become part of people’s daily commutes with the addition of an Express car pool to its ride-share options. Express Pool officially launched in a handful of US cities and was billed as an improvement on a car pool offering Uber has provided since 2014.Rather than have a driver travel to where each aspiring passenger requests a ride, the new Express option will use software to calculate the most direct path to the final destination and then have people walk to pick-up spots.”Riders wait a few minutes before their trips begin, and then walk a short distance to a nearby spot for pick up and drop off,” Uber shared rides product director Ethan Stock said in a release.”Walking and waiting help us make more optimal matches and provide better, straighter, faster routes with fewer detours, delivering an even more affordable and consistent option.”Car pooling leads to cheaper fares, and lets drivers take advantage of high-occupancy vehicle lanes on highways or discounted tolls where available.Nearly a billion riders have used Uber’s original car pool service, according to Stock.Using feedback from those riders, Uber “built the next generation of shared rides from the ground up,” Stock said.Why own cars?Uber software considers compatibility of passengers, proximity of drivers, and convenience of drop-off and pick-up locations, according to the San Francisco-based company.”The future of transportation in cities includes a shift towards more space-efficient modes of transportation and away from personal car ownership,” Zipcar co-founder Robin Chase said in the release.”Express Pool, in combination with public transit, cycling, car-sharing and more, can help us get towards this shift, and I’m extremely excited about the potential impact this product can have on cities.”A low-cost, convenient car pool service could also compete with public transit systems for commuter fares.Uber tested Express Pool in San Francisco and Boston, and is expanding it to six more US cities with the official launch this week.Uber, the titan in the ride share business, recently revealed that its losses last year swelled despite signs in the final three months that it was stemming the red ink.Figures reported by The Information and confirmed by AFP showed that Uber’s losses in 2017 grew to $4.5 billion from the $2.8 billion the San Francisco-based firm lost a year earlier.However, Uber lost $1.1 billion in the final quarter of 2017 as compared with $1.46 billion in the preceeding quarter as revenue rose.Net revenue grew to $2.22 billion from $1.38 billion in the same quarter-over-quarter comparison.Uber remains a private company, but routinely discloses some earnings information. Even as the company has seen unprecedented growth by expanding to dozens of countries, Uber has been hurt by allegations of executive misconduct, a toxic work atmosphere, and potentially unethical competitive practices.Dara Khosrowshahi, who was chosen as Uber CEO in August 2017, is steering the high-value startup to a stock market debut next year, and has vowed to fix the company’s work culture and business practices. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Uber’s express car pool option uses software to calculate the most direct path to the final destination and then has its customers meet at pick-up spots Uber loss leapt in 2017 as final quarter showed hope © 2018 AFP read more

4 ways internet of things toys endanger children

These toys wirelessly connect with online databases to recognize voices and images, identifying children’s queries, commands and requests and responding to them. They’re often billed as improving children’s quality of play, providing children with new experiences of collaborative play, and developing children’s literacy, numeric and social skills. Online devices raise privacy concerns for all their users, but children are particularly vulnerable and have special legal protections. Consumer advocates have raised alarms about the toys’ insecure wireless internet connections – either directly over Wi-Fi or via Bluetooth to a smartphone or tablet with internet access. As someone with both academic and practical experience in security, law enforcement and applied technology, I know these fears are not hypothetical. Here are four examples of when internet of things toys put kids’ security and privacy at risk. 1. Unsecured wireless connectionsSome “internet of things” toys can connect to smartphone apps without any form of authentication. So a user can download a free app, find an associated toy nearby, and then communicate directly with the child playing with that toy. In 2015, security researchers discovered that Hello Barbie, an internet-enabled Barbie doll, automatically connected to unsecured Wi-Fi networks that broadcast the network name “Barbie.” It would be very simple for an attacker to set up a Wi-Fi network with that name and communicate directly with an unsuspecting child. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. A cat-like stuffed toy orders real cat food. The toys’ ability to monitor children – even when used as intended and connected to official networks belonging to a toy’s manufacturer – violates Germany’s anti-surveillance laws. In 2017, German authorities declared the My Friend Cayla doll was an “illegal espionage apparatus,” ordering stores to pull it off the shelves and requiring parents to destroy or disable the toys.Unsecured devices allow attackers to do more than just talk to children: A toy can talk to another internet-connected device, too. In 2017, security researchers hijacked a CloudPets connected stuffed animal and used it to place an order through an Amazon Echo in the same room.2. Tracking kids’ movementsSome internet-connected toys have GPS like those in fitness trackers and smartphones, which can also reveal users’ locations, even if those users are children. In addition, the Bluetooth communications some toys use can be detected as far away as 30 feet. If someone within that range looks for a Bluetooth device – even if they’re only seeking to pair their own headphones with a smartphone – they’ll see the toy’s name, and know a child is nearby. For instance, the Consumer Council of Norway found that smartwatches marketed to children were storing and transmitting locations without encryption, allowing strangers to track children’s movements. That group issued an alert in its country, but the discovery led authorities in Germany to ban the sale of children’s smartwatches.3. Poor data protectionsInternet-connected toys have cameras that watch kids and microphones that listen to them, recording what they see and hear. Sometimes they send that information to company servers that analyze the inputs and send back directions on how the toy should respond. But those functions can also be hijacked to listen in on family conversations or take photographs or video of children without the kids or parents ever noticing. As Amazon releases an Echo Dot smart-home device aimed at children, it’s entering a busy and growing marketplace. More than one-third of U.S. homes with children has at least one “internet of things” connected toy – like a cuddly creature who can listen to and respond to a child’s inquiries. Many more of these devices are on the way, around the world and in North America specifically. The same thing could happen with unsecured Bluetooth connections to the Toy-Fi Teddy, I-Que Intelligent Robot and Furby Connect toys, a British consumer watchdog group revealed in 2017. Explore further This article was originally published on The Conversation. Read the original article. An 11-year-old shows government cyberprofessionals how easy it is to hack a teddy bear. Toy manufacturers don’t always ensure the data is stored and transmitted securely, even when laws require it: In 2018, toymaker VTech was fined US$650,000 for failing to fulfill its promises to encrypt private data and for violating U.S. laws protecting children’s privacy.4. Working with third partiesToy companies have also shared the information they collect about kids with other companies – much as Facebook shared its users’ data with Cambridge Analytica and other firms. And they can also surreptitiously share information from third parties with kids. One toy company came under fire, for example, in both Norway and the U.S. for a business relationship with Disney in which the My Friend Cayla doll was programmed to discuss what were described as the doll’s favorite Disney movies with kids. Parents weren’t told about this arrangement, which critics said amounted to “product placement”-style advertising in a toy.What can parents do?In my view, and according to consumer advice from the FBI, parents should carefully research internet-connected toys before buying them, and evaluate their capabilities, functioning, and security and privacy settings before bringing these devices into their homes. Without proper safeguards – by parents, if not toy companies – children are at risk, both individually and through collection of aggregate data about kids’ activities. Provided by The Conversation Citation: 4 ways ‘internet of things’ toys endanger children (2018, May 10) retrieved 18 July 2019 from https://phys.org/news/2018-05-ways-internet-toys-endanger-children.html Germany bans internet-connected ‘spying’ doll Cayla Are toys sharing too much information on the internet? Credit: mhong84/Shutterstock.com read more

-->

These toys wirelessly connect with online databases to recognize voices and images, identifying children’s queries, commands and requests and responding to them. They’re often billed as improving children’s quality of play, providing children with new experiences of collaborative play, and developing children’s literacy, numeric and social skills. Online devices raise privacy concerns for all their users, but children are particularly vulnerable and have special legal protections. Consumer advocates have raised alarms about the toys’ insecure wireless internet connections – either directly over Wi-Fi or via Bluetooth to a smartphone or tablet with internet access. As someone with both academic and practical experience in security, law enforcement and applied technology, I know these fears are not hypothetical. Here are four examples of when internet of things toys put kids’ security and privacy at risk. 1. Unsecured wireless connectionsSome “internet of things” toys can connect to smartphone apps without any form of authentication. So a user can download a free app, find an associated toy nearby, and then communicate directly with the child playing with that toy. In 2015, security researchers discovered that Hello Barbie, an internet-enabled Barbie doll, automatically connected to unsecured Wi-Fi networks that broadcast the network name “Barbie.” It would be very simple for an attacker to set up a Wi-Fi network with that name and communicate directly with an unsuspecting child. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. A cat-like stuffed toy orders real cat food. The toys’ ability to monitor children – even when used as intended and connected to official networks belonging to a toy’s manufacturer – violates Germany’s anti-surveillance laws. In 2017, German authorities declared the My Friend Cayla doll was an “illegal espionage apparatus,” ordering stores to pull it off the shelves and requiring parents to destroy or disable the toys.Unsecured devices allow attackers to do more than just talk to children: A toy can talk to another internet-connected device, too. In 2017, security researchers hijacked a CloudPets connected stuffed animal and used it to place an order through an Amazon Echo in the same room.2. Tracking kids’ movementsSome internet-connected toys have GPS like those in fitness trackers and smartphones, which can also reveal users’ locations, even if those users are children. In addition, the Bluetooth communications some toys use can be detected as far away as 30 feet. If someone within that range looks for a Bluetooth device – even if they’re only seeking to pair their own headphones with a smartphone – they’ll see the toy’s name, and know a child is nearby. For instance, the Consumer Council of Norway found that smartwatches marketed to children were storing and transmitting locations without encryption, allowing strangers to track children’s movements. That group issued an alert in its country, but the discovery led authorities in Germany to ban the sale of children’s smartwatches.3. Poor data protectionsInternet-connected toys have cameras that watch kids and microphones that listen to them, recording what they see and hear. Sometimes they send that information to company servers that analyze the inputs and send back directions on how the toy should respond. But those functions can also be hijacked to listen in on family conversations or take photographs or video of children without the kids or parents ever noticing. As Amazon releases an Echo Dot smart-home device aimed at children, it’s entering a busy and growing marketplace. More than one-third of U.S. homes with children has at least one “internet of things” connected toy – like a cuddly creature who can listen to and respond to a child’s inquiries. Many more of these devices are on the way, around the world and in North America specifically. The same thing could happen with unsecured Bluetooth connections to the Toy-Fi Teddy, I-Que Intelligent Robot and Furby Connect toys, a British consumer watchdog group revealed in 2017. Explore further This article was originally published on The Conversation. Read the original article. An 11-year-old shows government cyberprofessionals how easy it is to hack a teddy bear. Toy manufacturers don’t always ensure the data is stored and transmitted securely, even when laws require it: In 2018, toymaker VTech was fined US$650,000 for failing to fulfill its promises to encrypt private data and for violating U.S. laws protecting children’s privacy.4. Working with third partiesToy companies have also shared the information they collect about kids with other companies – much as Facebook shared its users’ data with Cambridge Analytica and other firms. And they can also surreptitiously share information from third parties with kids. One toy company came under fire, for example, in both Norway and the U.S. for a business relationship with Disney in which the My Friend Cayla doll was programmed to discuss what were described as the doll’s favorite Disney movies with kids. Parents weren’t told about this arrangement, which critics said amounted to “product placement”-style advertising in a toy.What can parents do?In my view, and according to consumer advice from the FBI, parents should carefully research internet-connected toys before buying them, and evaluate their capabilities, functioning, and security and privacy settings before bringing these devices into their homes. Without proper safeguards – by parents, if not toy companies – children are at risk, both individually and through collection of aggregate data about kids’ activities. Provided by The Conversation Citation: 4 ways ‘internet of things’ toys endanger children (2018, May 10) retrieved 18 July 2019 from https://phys.org/news/2018-05-ways-internet-toys-endanger-children.html Germany bans internet-connected ‘spying’ doll Cayla Are toys sharing too much information on the internet? Credit: mhong84/Shutterstock.com read more

Uber plans pollution levy on London fares

first_img A levy of 15 pence (17 euro cents) per mile will be introduced, resulting in an average additional cost of 45 pence per ride, Uber said in a statement.”The Mayor of London (Sadiq Khan) has set out a bold vision to tackle air pollution in the capital and we’re determined to do everything we can to back it,” said Uber chief executive Dara Khosrowshah.Uber said the amount drivers received toward the cost of an electric vehicle would be based on the number of miles (kilometres) driven. “For example, a driver using the app for an average of 40 hours per week could expect around £3,000 of support… in two years’ time and £4,500 in three years,” the company said.Uber wants to use only electric cars in London from 2025, while it anticipates the first 20,000 upgrades by the end of 2021.In June, Uber won a legal bid to restore its operating licence in London after a judge overturned an earlier decision by Khan—and granted the ride-hailing app a 15-month permit.The capital’s transport authority stripped the American firm of its licence in late 2017 amid safety concerns, but Uber appealed the decision and was allowed to continue operating while the case was heard.Earlier this month, Uber drivers in Britain went on strike, demanding higher fares and improved workers’ rights.Uber operates in 60 countries and is eyeing a valuation above $100 billion for its much-anticipated share offering due in 2019, which would be the biggest-ever in the tech sector. Citation: Uber plans pollution levy on London fares (2018, October 23) retrieved 17 July 2019 from https://phys.org/news/2018-10-uber-pollution-levy-london-fares.html Ride-sharing pioneer Uber plans a clean air levy in London to help combat pollution © 2018 AFP Uber will levy a “clean air fee” on London journeys from early 2019 to help tackle pollution and part-fund electric cars for its drivers, the pioneer ride-sharing app said Tuesday.center_img Explore further Uber’s London licence battle set for May/June This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

-->

first_img A levy of 15 pence (17 euro cents) per mile will be introduced, resulting in an average additional cost of 45 pence per ride, Uber said in a statement.”The Mayor of London (Sadiq Khan) has set out a bold vision to tackle air pollution in the capital and we’re determined to do everything we can to back it,” said Uber chief executive Dara Khosrowshah.Uber said the amount drivers received toward the cost of an electric vehicle would be based on the number of miles (kilometres) driven. “For example, a driver using the app for an average of 40 hours per week could expect around £3,000 of support… in two years’ time and £4,500 in three years,” the company said.Uber wants to use only electric cars in London from 2025, while it anticipates the first 20,000 upgrades by the end of 2021.In June, Uber won a legal bid to restore its operating licence in London after a judge overturned an earlier decision by Khan—and granted the ride-hailing app a 15-month permit.The capital’s transport authority stripped the American firm of its licence in late 2017 amid safety concerns, but Uber appealed the decision and was allowed to continue operating while the case was heard.Earlier this month, Uber drivers in Britain went on strike, demanding higher fares and improved workers’ rights.Uber operates in 60 countries and is eyeing a valuation above $100 billion for its much-anticipated share offering due in 2019, which would be the biggest-ever in the tech sector. Citation: Uber plans pollution levy on London fares (2018, October 23) retrieved 17 July 2019 from https://phys.org/news/2018-10-uber-pollution-levy-london-fares.html Ride-sharing pioneer Uber plans a clean air levy in London to help combat pollution © 2018 AFP Uber will levy a “clean air fee” on London journeys from early 2019 to help tackle pollution and part-fund electric cars for its drivers, the pioneer ride-sharing app said Tuesday.center_img Explore further Uber’s London licence battle set for May/June This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Opposition plans to take 2019 battle to States

first_imgSeptember 03, 2018 COMMENTS Hopes to blunt BJP’s leader-centric campaign; Rafale, note-ban to be highlights at rallies Published on To puncture the BJP’s campaign that the 2019 Lok Sabha elections are a direct fight between Prime Minister Narendra Modi and Congress President Rahul Gandhi, the Opposition is planning joint protest rallies against the Centre at various State capitals and major towns. The Rafale scam, demonetisation, and unemployment will be the key issues that will be discussed in these rallies.NCP supremo Sharad Pawar is learnt to have conveyed to various leaders of the Opposition that the focus on Delhi-based programmes will ultimately feed the BJP’s idea of dividing the Opposition over its prime ministerial face. The Left parties are of the opinion that livelihood issues of people must get prominence in the rallies. The Rafale fighter aircraft deal is a subject close to the Congress leadership’s heart.Pawar, who is holding regular meetings with Rahul Gandhi, CPI(M) General Secretary Sitaram Yechury, former JD(U) leader Sharad Yadav, and leaders of various political parties has communicated to the Opposition parties that ironing out differences at the State level is more important than projecting unity in Delhi. Talking to reporters here last week, Pawar had said that finding a leader will not be a tough job for the Opposition.Seat allocation mattersA senior leader who is aware of the discussions among Opposition parties said the real challenge was to iron out differences over seat allocation.“This must be done at the State-level. The Central leaderships of the Opposition parties do not have much to do in the seat-sharing process. A national-level alliance is not viable and not possible. But experiments can be done at State-level,” the leader added.The Opposition considers that the programme organised by Sharad Yadav at Talkatora Statdium was a success and a large number of people were in attendance. “Such rallies can be held at State capitals and other major towns. Issues such as demonetisation, unemployment, farmers’ distress and Rafale scam have attracted people’s attention,” another leader said.The Left parties are also planning large-level mobilisations of peasants and workers at various Centres, including a massive rally in Delhi on Wednesday.‘BJP is the enemy of the poor’“Our effort is to make the poor people understand who their real enemy is. Unless these policies change, their lives cannot be improved,” CPI(M) Polit Bureau member Tapan Sen said.“The Modi government is imposing their communal agenda and implementing their regressive economic policies on the strength of their large numbers in the Lok Sabha, forgetting the fact that only 31 per cent of the voters had voted for them in 2014,” said a resolution adopted by NCP National Council. national politicscenter_img SHARE COMMENT Kite-flying? The Congress believes it has managed to strike a chord with the people by raising issues surrounding the Rafale fighter aircraft deal   –  PTI SHARE SHARE EMAILlast_img read more

-->

first_imgSeptember 03, 2018 COMMENTS Hopes to blunt BJP’s leader-centric campaign; Rafale, note-ban to be highlights at rallies Published on To puncture the BJP’s campaign that the 2019 Lok Sabha elections are a direct fight between Prime Minister Narendra Modi and Congress President Rahul Gandhi, the Opposition is planning joint protest rallies against the Centre at various State capitals and major towns. The Rafale scam, demonetisation, and unemployment will be the key issues that will be discussed in these rallies.NCP supremo Sharad Pawar is learnt to have conveyed to various leaders of the Opposition that the focus on Delhi-based programmes will ultimately feed the BJP’s idea of dividing the Opposition over its prime ministerial face. The Left parties are of the opinion that livelihood issues of people must get prominence in the rallies. The Rafale fighter aircraft deal is a subject close to the Congress leadership’s heart.Pawar, who is holding regular meetings with Rahul Gandhi, CPI(M) General Secretary Sitaram Yechury, former JD(U) leader Sharad Yadav, and leaders of various political parties has communicated to the Opposition parties that ironing out differences at the State level is more important than projecting unity in Delhi. Talking to reporters here last week, Pawar had said that finding a leader will not be a tough job for the Opposition.Seat allocation mattersA senior leader who is aware of the discussions among Opposition parties said the real challenge was to iron out differences over seat allocation.“This must be done at the State-level. The Central leaderships of the Opposition parties do not have much to do in the seat-sharing process. A national-level alliance is not viable and not possible. But experiments can be done at State-level,” the leader added.The Opposition considers that the programme organised by Sharad Yadav at Talkatora Statdium was a success and a large number of people were in attendance. “Such rallies can be held at State capitals and other major towns. Issues such as demonetisation, unemployment, farmers’ distress and Rafale scam have attracted people’s attention,” another leader said.The Left parties are also planning large-level mobilisations of peasants and workers at various Centres, including a massive rally in Delhi on Wednesday.‘BJP is the enemy of the poor’“Our effort is to make the poor people understand who their real enemy is. Unless these policies change, their lives cannot be improved,” CPI(M) Polit Bureau member Tapan Sen said.“The Modi government is imposing their communal agenda and implementing their regressive economic policies on the strength of their large numbers in the Lok Sabha, forgetting the fact that only 31 per cent of the voters had voted for them in 2014,” said a resolution adopted by NCP National Council. national politicscenter_img SHARE COMMENT Kite-flying? The Congress believes it has managed to strike a chord with the people by raising issues surrounding the Rafale fighter aircraft deal   –  PTI SHARE SHARE EMAILlast_img read more