When the lineup for the New Orleans Jazz & Heritage Festival was revealed, one entry caught our eye: Tedeschi Trucks Band & Friends. The group certainly has a lot of friends, so who would be sitting in with them for their prized performance spot at one of the world’s most renowned festivals.Today we have the answer, as guitarists Jimmie Vaughan and Billy Gibbons will be making an appearance as the friends of the band. Vaughan is perhaps best known as the brother of the late Stevie Ray Vaughan, though has flourished in his own career as the leader of the Fabulous Thunderbirds. Meanwhile, Gibbons has enjoyed a long tenure as a founding member of ZZ Top.Both musicians have collaborated with the TTB family, including Vaughan, who recently sat in with the group at the Beacon Theatre back in September. Watch below:While Gibbons hasn’t performed with the group, he has crossed paths with guitarist Derek Trucks in recent years. Watch below:Tedeschi Trucks Band is touring on the heels of their recently-released Let Me Get By, and have major tour plans in the works. Don’t miss this band on the road, as they breathe exceptional soul into all of their rockin’ music. More info about their Jazz Fest set can be found here.
Scientists at the Harvard-affiliated Dana-Farber Cancer Institute say they have identified the root molecular cause of a variety of ills brought on by advanced age, including waning energy, failure of the heart and other organs, and metabolic disorders such as diabetes.“What we have found is the core pathway of aging connecting several age-related biological processes previously viewed as independent of each other,” said Ronald A. DePinho, senior author of a report posted online by the journal Nature. The first author, Ergun Sahin, is a member of the DePinho Lab and an instructor in medicine at Harvard Medical School (HMS).DePinho, who is the director of Dana-Farber’s Belfer Institute for Applied Cancer Science and also a professor of medicine at HMS, said that although the studies were conducted in mice, “The findings bear strong relevance to human aging, as this core pathway can be directly linked to virtually all known genes involved in aging, as well as current targeted therapies designed to mitigate the toll of aging on health.”The scientists found that the basic cause of age-related health decline is malfunctioning telomeres — the end caps on cells’ chromosomes that protect them against DNA damage. As cells reach their predetermined limit of times that they can divide, the telomeres become shortened and frayed, making the chromosomal ends vulnerable to increased rates of unrepaired DNA damage.Faced with this increasing reservoir of injured DNA, cells activate a gene, p53, that sounds an alarm and shuts down the cells’ normal growth and division cycle, ordering them to rest until the damage can be repaired or, if not, to self-destruct.Scientists previously had blamed this emergency shutdown and cell death for age-related deterioration of organs whose cells divide rapidly and are rejuvenated by reserves of adult stem cells. Such tissues include skin, intestinal lining, and blood cells, among others, which generate trillions of new cells each day of life.However, left unanswered is how cells with less cell division, such as the heart or the liver, sustain equivalent levels of aging. The scientists felt if they could solve this mystery, they might gain new insights into how DNA damage could lead to age-related decline across all organs.The new findings demonstrate that the telomere dysfunction and activation of p53 also trigger a wave of cellular and tissue degeneration that links telomeres to well-known mechanisms of aging that are not simply related to rapid growth and division. In other words, telomere dysfunction is not just one culprit in the declining health of advanced age. It’s the kingpin, according to DePinho and his colleagues.DePinho published a study in Nature in January 2011 that demonstrated it was possible to reverse the symptoms of extreme aging in mice by increasing their levels of telomerase, the enzyme that maintains the health of the telomeres.In this new, larger role, the telomere dysfunction also sets off an array of reactions leading to diminished health and longevity. For example, muscles suffer a loss of mitochondria, a cell’s chemical power plant, causing waning vitality and failure of the heart and other organs. Risks of metabolic disorders such as diabetes are increased.In addition, the process weakens the body’s antioxidant defenses against the damaging molecules known as reactive oxygen species, or “free radicals,” that accumulate with age and exposure to stress. Until now, some researchers had labeled the decline in mitochondria or the buildup of free radicals as the primary causes of age-related ills. The new work integrates these seemingly disparate mechanisms into one unified theory of aging.Telomere dysfunction causes this wave of metabolic and organ failure, the scientists found, because when the p53 gene is activated, it represses the functions of two master regulators of metabolism, PGC1-alpha and PGC1-beta. This dialing down of the regulators diminishes metabolic processes needed to provide energy and resist stress. In the mouse experiments, the scientists showed that “knocking out” p53 in mice released the brakes on PGC1-alpha and PGC1-beta.“This is the first study that directly links telomere dysfunction to regulators of the mitochondria and antioxidant defense via p53,” DePinho said. “The discovery of this new pathway of aging integrates a lot of different ideas people have had and gives us a better understanding of the aging process.”By unifying several major pathways of aging under the umbrella of telomere dysfunction, he said, the findings may yield new targets for therapies. The discoveries also may underlie the relatively sudden and rapid failure of the body leading to the end of life.“Because telomere dysfunction weakens defenses against damage by free radicals, or reactive oxygen species,” DePinho said, “we think this exposes telomeres to an accelerated rate of damage which cannot be repaired and thereby results in even more organ deterioration. In effect, it sets in motion a death spiral.”In addition to DePinho and Sahin, the paper’s other authors include faculty members from Dana-Farber, the Belfer Institute for Applied Cancer Science at Dana-Farber; Harvard University; Harvard Medical School; the Boston University School of Medicine; Brigham and Women’s Hospital; the University of Massachusetts, Worcester; and St. Vincent’s Hospital, University of Melbourne, Australia.The research was funded in part by the National Cancer Institute and the Robert A. and Renee E. Belfer Foundation.
This is one in a series of profiles showcasing some of Harvard’s stellar graduates.Growing up between Lawrence, Kan., and Seoul, South Korea, gave Jisung Park different and distinct insights into how humans and nature intersect. Park recalls as a young boy spending every waking hour exploring the Kansas outdoors. Still a youngster when he moved to Seoul, living in its dense, urban environment revealed the toll that industrialization exacts on air and water quality.“I was always acutely aware of how human beings and society both affect and are affected by the natural environment,” said Park, who will graduate in May with a Ph.D. in economics from the Harvard Graduate School of Arts and Sciences. “Through experiencing the diversity of living in such different places, I grew to appreciate how much commonality there is in the basic humanity that we share.”His introductory economics class in high school gave him an entirely new lens with which to view the world — and think about studying it. In his undergraduate coursework at Columbia University, Park recognized that economics could be a tool for generating a greater understanding of the intersection of humans and nature.After his Rhodes Scholarship at Oxford University, Park joined the environmental economics program at Harvard to focus specifically on how the impacts of climate change will affect human productivity and economic health.“He has broken new ground with his research on weather, climate, and human capital, and will soon be moving on to a great career as an innovative scholar,” said Robert Stavins, the Albert Pratt Professor of Business & Government at Harvard Kennedy School and director of the Harvard Environmental Economics Program.Park says the motivation for his research is the fundamental disconnect in the public’s mind between recognizing climate change as a problem in the abstract sense but not being able to relate to the immediate impacts that may already be affecting the local community or region.“I was frustrated by this phenomenon that climate change was becoming an issue that, unless you are an ardent environmentalist, you weren’t allowed to comment about or care about,” said Park. “I wanted to use language and tools of economics to try and quantify the more direct impacts of climate change on human beings and human economy, to try and make it a little more real.”At a time when much attention is on rising sea levels and extreme weather events, Park eagerly took on the challenge of developing a greater understanding of the correlation between long-term economic vitality and rising temperatures due to global warming. As one of the first grantees of the President’s Climate Change Solutions Fund, Park explored the affect heat stress will have on labor productivity. According to Park, a year with 10 or more 90-degree-plus days in the United States could reduce income or output per capita by 3 percent. For context, he points to the fact that the Great Recession led to a percentage drop in GDP of that magnitude.Park says the grant opened doors and allowed him to engage with a wide variety of research institutions inside and outside of Harvard, including presenting his research to the World Bank and New York City government agencies.“It’s good to know there is institutional support for interdisciplinary research like this and that the support comes close to the top,” Park said. “It speaks to the direction in which the university wants to move in terms of priorities.”While at Harvard, Park presented what New York Times columnist Nicholas Kristof called a “clever new working paper” exploring the impact of hotter temperatures on student test scores and academic performance in New York City schools. He found that students taking a test on a 90-degree day relative to a 72-degree day have a 12 percent higher likelihood of failing. “You may not have seen a polar bear but you’ve definitely been in a classroom that was hot,” said Park.Park brought with him from Oxford a podcast project called Sense & Sustainability that started as a series of conversations with fellow students on topics related to sustainability. At Harvard, the organization took off, receiving a Student Sustainability Grant from the Harvard Office for Sustainability and expanding to a lively blog and weekly meetings of undergraduate and graduate fellows to share ideas.“It’s hard to have conversations across disciplines but also very rewarding, because it forces you to think outside your disciplinary focus or bias,” said Park. “It’s amazing how different our conceptions are of what sustainability is, and it opened me up to the diversity of ways one can conceptualize sustainability.”Park plans to complete a postdoc at Harvard Kennedy School on climate policy, then join the faculty at University of California, Los Angeles, as part of a joint public policy and public health program, where he will continue his research into the environmental determinants of economic mobility.“The more you look at direct economic impacts of climate change, the more it begins to become clear it will be disadvantaged segments of society — both within countries but also across the world — that are going to be disproportionately affected,” said Park. “Climate change is the ultimate global public good problem, and that certainly is a motivation for me.”
A few weeks ago, I attended a small credit union conference in Rapid City, South Dakota.I love going to these events not only for the networking abilities, but also for the variety of presenters. I truly love to meet new people. It is kind of my jam.This event had about 65 people in attendance and was an intimate enough setting that you could really get to know people. As we were all in line for lunch one particular day, I was speaking with two attendees behind me.I use my hands when I talk. In fact, I use them more so than I had initially thought.Mix that in with the fact that I am short, and this could become hazardous.On this particular day it was.I was neck deep in some sort of riveting story (I’m sure…) and I swayed my left arm out to the side in a dramatic fashion.This would have been just like any other story of mine, however this time my dramatic hand made a dramatic slap on the gentleman’s behind ahead of me.It wasn’t just a small smack. It was a dramatic one.There was a brief moment of silence before my mouth decided that it just could not be quiet.“My name is Nanci. There. Now we know each other so the fact that I touched your rear isn’t weird”.Not missing a beat, the gentleman said “Hi, I work in HR”.“So…” I continued “Do I turn myself in or how does this work?”Everyone had a nice laugh and jokes peppered the rest of the event as people would go up against a wall when I would pass by so that I would not accidentally hit their behind too.As recent as a few years ago, I would have wanted the earth to suck me up into a large hole before I acknowledged that I had done such a thing.I used to be quiet content pretending that these things did not happen and definitely not to me.However, as the years have gone by I have realized that even in professional settings allowing people to see that you are not perfect can create authentic connections.Nothing is more intimidating nor annoying than someone pretending to be perfect.Whether this is in the work that they do or the actions that they take, when someone does not admit their shortcomings it becomes a show of who can save face the best.I’ve realized in my years that ignoring my imperfections only allows me to hide and owning them allows me to connect.I’d rather connect.There is freedom in having people laugh with you.There is power in being able to make what could be an uncomfortable moment, comfortable.Everyone craves human connection whether they admit it or not.We crave authentic moments where the guard can come down and the extremely imperfect human can rise to the occasion with laughter.It is OKAY to do this in both your personal life as well as your professional.Rising to the imperfect occasion, owning it, and allowing others to see it gives you the unique ability to connect through human nature. There isn’t anything more organic than that!Now I am not saying go directly to your HR person and smack their rear.Bad idea.Don’t do that.I am just simply saying, imperfections are something we all share.It is a common thread in the link of humanity.Why not take that and use it for good?Your coworkers and employees will find great relief in your ability to call yourself out and be keener on doing it themselves.This not only creates an atmosphere of honesty, but also an atmosphere of integrity.Sometimes the “magical element” isn’t something you can pull off a shelf or teach in a classroom.Sometimes that element is simply using what is already there and making it work. 75SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr,Nanci Wilson Nanci started her credit union journey due to lack of kindness.That fact is what led her to close her bank account and open up at a credit union.Ultimately … Web: https://www.universityfederalcu.org Details
(WBNG) — Endicott native and Arizona Cardinals linebacker Chandler Jones is giving back during this time of crisis, donating 150,000 meals to food banks in Arizona and Endicott, NY. “Like” Nicole Menner on Facebook and “Follow” her on Twitter. As we all deal with the uncertainty of when this crisis will end, Jones urges everyone to listen to the guidelines being set forth, and to keep busy doing the little thing. Jones donated meals to Mother Teresa’s Cupboard through Catholic Charities of Broome County, helping those effected by the coronavirus. “Endicott, New York is the city that raised me. Raised me and my family. When we moved from Rochester they welcomed us with open arms. The city has done so much for us. My biggest thing was just trying to give back, and trying to help because this is a serious situation and I feel like that donation would definitely help,” said Jones. Jones has been with the Cardinals since 2016, and since that time he leads the NFL with 60 sacks, and is tied for second in forced fumbles with 17. Jones says that he is fortunate enough to have an at-home gym, and COVID-19 has not impacted his training routine. “It’s been different like I said, I’ve never experienced anything like it. My biggest thing now is keeping a routine, keeping myself busy and keeping active. That’s been one thing that can be a little mentally challenging, but I feel like in times like this having mental toughness is huge,” said Jones. “Try listening, make sure you wash your hands make sure you are disinfecting everything because this is a real thing and it’s really happening. My biggest fright is people aren’t taking this serious. So that’s my biggest thing. Don’t go crazy, stay home, be home. Play with your friends, talk on the phone, and stay busy. That’s my biggest thing,” said Jones. “Like” Jacob Seus on Facebook and “Follow” him on Twitter. While the NFL season has yet to be impacted by coronavirus, as an athlete, Jones opened up about what this time has been like for him.
The Istrian tourist region has received another recognition that confirms what has long been known – Istria is the pinnacle of Croatian tourism. Along with the recognition, of course comes the top tourist promotion of the Istrian offer.Namely, the world’s most influential lifestyle magazine Forbes, has listed Istria among six European tourist destinations, there are also the French Autoroute du Soleil, Italian Matera, the Irish “Emerald Islands” and the route La Dolce Vita (Italy and France), which “must” be visited although they are insufficiently known to the general tourist public, they are “among the most complete late summer and early autumn destinations”.”While the Dalmatian coast is known for its islands and tourist towns, experts from local luxury destinations direct visitors to the north of the country. Istria is known for its exceptional gastronomy, beautiful landscapes, green hills and miraculous historical monuments. It is one of the few regions in the world where noble mushrooms can be found – black and white truffles. A truffle hunt was organized with real hunters and their dogs, as well as tasting lunches with local traditional products enriched with truffles. The region is also home to excellent wines, under the protection of UNESCO is the Euphrasian Basilica in Porec and its mosaics from the 6th century, and the network of local roads runs from the coast and beautiful stone towns to the hilly interior: Motovun, Grožnjan, Bale, Svetvincenat and many vineyards, olive groves, small family farms, studios and galleries“, Describe in Forbes the beauty of Istria.
Thousands of people from various labor groups and farmer unions as well as university students staged a rally in front of the House of Representatives complex in Senayan, Central Jakarta, on Thursday to protest the ongoing deliberation of the controversial omnibus bill on job creation as well as the Pancasila Ideology Guidelines (HIP) bill.The protesters were joined in a coalition named the Labor with the People Movement (GEBRAK), comprising members of the Congress Alliance of Indonesian Labor Unions (KASBI), the Agrarian Reform Consortium (KPA) and the Indonesia Youth Movement (AKMI), among other groups.KASBI chairwoman Nining Elitos said the protesters demanded lawmakers stop the deliberation of the job creation omnibus bill and prioritize other bills that would ensure the well-being and safety of citizens, such as the sexual violence eradication (RUU PKS) and domestic workers protection bills. The draft bill, which seeks to amend 79 prevailing laws and more than 1,200 articles, has been opposed by labor unions, who claimed the bill would undermine labor rights and only benefit employers and corporations.Read also: Most Indonesians who are aware of job creation bill support it: SurveySeveral labor groups withdrew from a Manpower Ministry technical team tasked with discussing the labor section of the omnibus bill after their demands to play a greater role in the bill’s deliberations were rejected. The technical team also includes representatives of business associations, such as the Indonesian Employers Association (Apindo) and the Indonesian Chamber of Commerce and Industry (Kadin).Coordinating Economic Minister Airlangga Hartarto said he hoped lawmakers could finish deliberating the omnibus bill by the end of this month, as he claimed they had finished “half of the [bill’s] chapters”. In a 34-page statement, GEBRAK said the bill would hurt workers who were already suffering from the economic impacts of the COVID-19 pandemic.”[Workers] have received no protections or safety nets [during the pandemic], while the government has not strictly punished employers who have violated our rights. This bill only sells Indonesian citizens as cheap labor for investors,” the statement read. A coalition of customary forest communities have also objected to the omnibus bill, claiming it would make it easier for corporations to seize indigenous lands and forests and would cause economic disparities to increase, especially for people who live in forest areas.On the same day, the Anti-Communist National Alliance (ANAK), comprising members of 174 mass organizations, also staged a protest against the deliberations of the HIP bill.The bill, supported by the ruling Indonesian Democratic Party of Struggle (PDI-P), aims to regulate the values of the state ideology Pancasila as well as the Agency for Pancasila Ideology Education (BPIP). The party’s chairwoman and former president Megawati Sukarnoputri is currently serving as the BPIP steering committee head.Indonesian Legal Aid Institute (YLBHI) chairwoman Asfinawati previously expressed concerns that the bill could harm the country’s freedom of expression, claiming there was an effort to monopolize the interpretation of the state ideology as stipulated in Article 45 of the bill. She also highlighted that Article 48 of the draft bill allows for positions in the BPIP steering committee to be filled by active military and police personnel.Topics : “We also urge the House to revoke the recently-passed Mining Law revision and focus on mitigating the impacts of the COVID-19 pandemic across the nation,” Nining said on Thursday.Jakarta Police traffic division chief Sr. Comr. Sambodo Purnomo Yogo said around 3,600 officers were deployed to secure the rally.”[We] deployed between 3,400 to 3,600 personnel in two shifts to secure the rally as well as manage traffic around the area,” he said on Thursday as quoted by tempo.co.Labor groups, activists and members of the general public have repeatedly criticized the House and the government of trying to push through controversial bills. Opposition to the omnibus bill on job creation has only grown as the country faces mass layoffs because of the economic slowdown caused by the COVID-19 pandemic.
Norwegian offshore safety watchdog, the Petroleum Safety Authority (PSA), has found irregularities during an audit of Vår Energi’s management of major accident risk and barriers on the Balder FPU off Norway.Balder FPU; Image by: Benjamin Duivesteyn; Source: Flickr – under the CC BY 2.0 licenseThe PSA said on Monday that it carried out the audit on Vår Energi’s Balder FPU in weeks 6 and 8 of 2019.The safety body added that Point Resources, before becoming a part of Vår Energi, applied for consent for a life extension to 2030 for Balder.Vår Energi was formed in December 2018 through a merger of Eni Norge and Point resources. The company claims to have reserves and resources of more than 1,250 million barrels of oil equivalent.According to the Norwegian watchdog, this audit will form part of the basis for processing the application.The objective of the audit was to assess how Vår Energi is ensuring compliance with the authorities’ and its requirements in relation to the management of major accident risk and barriers at Balder.The PSA identified non-conformities regarding the management of major accident risk and barriers, follow-up of barriers, barrier deteriorations and compensatory measures, barrier strategy and performance standards, management of change, process safety, ignition source control, fire resistance, temporary equipment and installations.Other non-conformities are linked with labeling, maintenance program, documentation, deck gratings made from composites in evacuation routes.Also, improvement points were found regarding planning and prioritization and classification.Vår Energi was told to report on how the non-conformities and improvement points would be addressed by June 20, 2019, at the latest.Spotted a typo? Have something more to add to the story? Maybe a nice photo? Contact our editorial team via email. Offshore Energy Today, established in 2010, is read by more than 10.000 industry professionals daily.We had almost 9 million page views in 2018, with 2.4 million new users. This makes us one of the world’s most attractive online platforms in the space of offshore oil and gas.These stats allow our partners advertising on Offshore Energy Today to get maximum exposure to their online campaigns. If you’re interested in showcasing your company, product or technology on Offshore Energy Today contact our marketing manager Mirza Duran for advertising options.
Damen Shipyards has floated out HST Euan, High Speed Transfers’ (HST) fourth FCS 2710 class fast crew supply vessel.Source: HSTTo remind, HST placed the order with Damen for the fourth Fast Crew Supplier (FCS) 2710 this June.Shortly after, the company revealed it had signed a contract with MHI Vestas to provide HST Euan and HST Harri for the Northwester 2 offshore wind project in Belgium.Damen unveiled the FCS 2710 class in May last year. The vessels are capable of carrying 26 passengers and are able to operate in wave heights of more than 2m due to an extra meter of freeboard.The first FCS 2710, HST Hudson, was named in July 2018, while the second vessel, HST Sofia, was launched this March.Source: HST
I know that on the calendar the middle of summer is still a few weeks away; however, to school children the middle of summer is past. In 3 short weeks they will be back in school!For the school administrators, this calendar makes a lot of sense. Their job is to provide the best possible education for the taxpayer dollar. This means keeping the buildings in use as many weeks in a year as they can. When schools set empty for long periods of time, many systems must be shut down and their re-start is quite expensive. The continuous calendar helps to eliminate this.For the athlete, their only real vacation from sports is the moratorium week that the IHSAA designates. The full-time athlete knows that when the first of August rolls around they are back in the swing. That is not a very long vacation for a young student athlete.The coaches have very little choice in this. Their hands are tied by the trend that is in place today. If you do not play the sport full-time, you can’t compete at a winning level. We all know that kids are supposed to play for the fun of it, but we also know coaches get fired when their teams don’t win.